解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization on CTCs w...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.15359
更新日期:2016-06-15 00:00:00
abstract::Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.15081
更新日期:2016-06-05 00:00:00
abstract::Peripheral arterial disease affects nearly 202 million individuals worldwide, sometimes leading to non-healing ulcers or limb amputations in severe cases. Genetically modified stem cells offer potential advantages for therapeutically inducing angiogenesis via augmented paracrine release mechanisms and tuned dynamic re...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.12866
更新日期:2016-05-23 00:00:00
abstract::Treatments of high specificity are desirable for cancer therapy. Light-triggered nanotheranostics (LTN) mediated cancer therapy could be one such treatment, as they make it possible to visualize and treat the tumor specifically in a light-controlled manner with a single injection. Because of their great potential in c...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.15217
更新日期:2016-04-27 00:00:00
abstract::Fast clearance, metabolism and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present these defects despite displaying promising anti-tumor properties on tumor cells in vitro and in in vivo model of cancers. Specific delivery of anti-cancer drugs in...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.13725
更新日期:2016-03-25 00:00:00
abstract::Cell sheet technology opens new perspectives in tissue regeneration therapy by providing readily implantable, scaffold-free 3D tissue constructs. Many studies have focused on the therapeutic effects of cell sheet implantation while relatively little attention has concerned the fate of the implanted cells in vivo. The ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.14064
更新日期:2016-03-21 00:00:00
abstract::Cell-derived microparticles (MPs) are nano-sized vesicles released by activated cells in the extracellular milieu. They act as vectors of biological activity by carrying membrane-anchored and cytoplasmic constituents of the parental cells. Although detection and characterization of cell-derived MPs may be of high diag...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.13757
更新日期:2016-03-02 00:00:00
abstract::Aberrant activation of the Src kinase is implicated in the development of a variety of human malignancies. However, it is almost impossible to monitor Src activity in an in vivo setting with current biochemical techniques. To facilitate the noninvasive investigation of the activity of Src kinase both in vitro and in v...
journal_title:Theranostics
pub_type: 杂志文章,收录出版
doi:10.7150/thno.14306
更新日期:2016-02-24 00:00:00
abstract::Many drug controlled release methods have been integrated in multifunctional nanoparticles, such as pH-, redox-, temperature-, enzyme-, and light-responsive release. However, few report is associated with the ROS responsive drug controlled release. Herein, a thioketal linker-based ROS responsive drug (camptothecin con...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.14101
更新日期:2016-02-05 00:00:00
abstract::The combination of chemotherapy and RNA interference is a promising approach for efficient cancer therapy. However, the success of such a strategy is hampered by the lack of suitable vectors to coordinate small interfering RNA (siRNA) and chemotherapeutic drug into one single platform. We herein report a novel triple-...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.13515
更新日期:2016-01-01 00:00:00
abstract::One of the major challenges in the hepatocellular carcinoma (HCC) treatment is its insensitivity to chemotherapeutic drugs. Here, we report the development of novel lipid-coated cisplatin nanoparticles co-loaded with microRNA-375 (NPC/miR-375) as a potential treatment for chemotherapy insensitive HCC. The NPC/miR-375 ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.13130
更新日期:2016-01-01 00:00:00
abstract::Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.13178
更新日期:2016-01-01 00:00:00
abstract::Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.11918
更新日期:2016-01-01 00:00:00
abstract::Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent thrombus organization limits direct blood contact with fibrin, the target of blood-based fibri...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.12494
更新日期:2015-09-13 00:00:00
abstract::In a report from 2008, The International Agency for Research on Cancer predicted a tripled cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by 2030. While new treatments are evolving and reaching approval for different cancer types, the main prevention of cancer mortality is thro...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.11544
更新日期:2015-09-01 00:00:00
abstract::Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of several human cancers, including breast cancer (BC), as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. This review presents the state of the art on the role of miRNAs in the diagnosis, progn...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.11543
更新日期:2015-07-13 00:00:00
abstract::The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat an...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.11802
更新日期:2015-05-20 00:00:00
abstract::To enhance effective drug accumulation in drug-resistant tumors, a site-specific drug-releasing polypeptide system (PEG-Phis/Pasp-DOX/CA4) was exploited in response to tumor extracellular and intracellular pH. This system could firstly release the embedded tumor vascular inhibitor (CA4) to transiently 'normalize' vasc...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.11821
更新日期:2015-04-28 00:00:00
abstract::Successful anticancer chemotherapy requires targeting tumors efficiently and further potential to eliminate cancer stem cell (CSC) subpopulations. Since CD44 is present on many types of CSCs, and it binds specially to hyaluronic acid (HA), we tested whether coating solid lipid nanoparticles with hyaluronan (HA-SLNs)wo...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.10804
更新日期:2015-04-05 00:00:00
abstract::Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we d...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.11222
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:Ultrasound molecular imaging (UMI) of glycoprotein (GP) IIb/IIIa receptor on activated platelets offers a unique means of identifying high-risk atherosclerosis. We hypothesized that contrast-enhanced ultrasound with microbubbles (MBs) targeted to GP IIb/IIIa could be used to detect and quantify activated plat...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.10020
更新日期:2015-02-05 00:00:00
abstract::To generate a more efficient in vivo reporter and therapeutic gene, we optimized the coding sequence of the human sodium/iodide symporter (NIS) gene by replacing NIS DNA codons from wild type to new codons having the highest usage in human gene translation. The Codon Adaptation Index (CAI), representing the number of ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.10062
更新日期:2015-01-01 00:00:00
abstract::A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positi...
journal_title:Theranostics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.7150/thno.10636
更新日期:2015-01-01 00:00:00
abstract::Small interfering RNA (siRNA) has proved to be a powerful tool for target-specific gene silencing via RNA interference (RNAi). Its ability to control targeted gene expression gives new hope to gene therapy as a treatment for cancers and genetic diseases. However, siRNA shows poor pharmacological properties, such as lo...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.8491
更新日期:2014-09-19 00:00:00
abstract::RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mice when administered...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.7866
更新日期:2014-08-13 00:00:00
abstract:PURPOSE:The ability to longitudinally monitor cell grafts and assess their condition is critical for the clinical translation of stem cell therapy in regenerative medicine. Developing an inducible genetic magnetic resonance imaging (MRI) reporter will enable non-invasive and longitudinal monitoring of stem cell grafts ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.9436
更新日期:2014-07-27 00:00:00
abstract:PURPOSE:The efficacy of pro-angiogenic therapy is difficult to evaluate with current diagnostic modalities. The objectives were to develop a non-invasive imaging strategy to define the temporal characteristics of angiogenesis and to evaluate the response to pro-angiogenic therapy in diabetic stroke mouse models. METHO...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.9525
更新日期:2014-05-25 00:00:00
abstract::This paper reports a sensitive method with electrochemical technique to detect various proteases, which can be used for the diagnosis of prostate cancer. For the proposed assay method, the working electrode is modified with the peptide probes for the target proteases. These probes contain the substrate sequence of tar...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.8803
更新日期:2014-04-25 00:00:00
abstract::Natural polysaccharides have received a lot of attention in the biomedical field. Indeed, sources of polysaccharides, extracted or produced from plants, bacteria, fungi or algae, are diverse and renewable. Moreover, recent progresses in polysaccharide chemistry and nanotechnologies allow elaborating new dedicated nano...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.7688
更新日期:2014-03-11 00:00:00
abstract::Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical behavior and require therapies specially tailored according to staging, grading, origin and expression of peptide receptors. Despite extensive scientific efforts, the therapy options are still not satisfactory. The main reasons are due...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.7851
更新日期:2014-01-29 00:00:00
abstract::MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.7552
更新日期:2014-01-02 00:00:00
abstract::Dynamic positron emission tomography (PET) can monitor spatiotemporal distribution of radiotracer in vivo. The spatiotemporal information can be used to estimate parametric images of radiotracer kinetics that are of physiological and biochemical interests. Direct estimation of parametric images from raw projection dat...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5130
更新日期:2013-11-20 00:00:00
abstract::Model observers play an important role in the optimization and assessment of imaging devices. In this review paper, we first discuss the basic concepts of model observers, which include the mathematical foundations and psychophysical considerations in designing both optimal observers for optimizing imaging systems and...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5138
更新日期:2013-10-04 00:00:00
abstract::Stem cell tracking is a highly important subject. Current techniques based on nanoparticle-labeling, such as magnetic resonance imaging, fluorescence microscopy, and micro-computed tomography, are plagued by limitations including relatively low sensitivity or penetration depth, involvement of ionizing irradiation, and...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.5369
更新日期:2013-07-19 00:00:00
abstract::With the newly released impact factor from Thomson Reuters, we look at the first two years of the journal Theranostics under the scope of a new bibliometric designed for the analysis of emerging specialties and also for journals with a multidisciplinary approach. With this method, we are able to look at characteristic...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.7021
更新日期:2013-07-03 00:00:00
abstract::In biology, as every science student is made to learn, ontology recapitulates phylogeny. In medicine, however, oncology recapitulates polemology, the science of warfare: The medical establishment is transitioning from highly toxic poisons that kill rapidly dividing normal and malignant cells with little specificity to...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5658
更新日期:2013-05-25 00:00:00
abstract::Optical sensing plays an important role in theranostics due to its capability to detect hint biochemical entities or molecular targets as well as to precisely monitor specific fundamental psychological processes. Rare-earth (RE) doped upconversion nanoparticles (UCNPs) are promising for these endeavors due to their un...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5305
更新日期:2013-03-26 00:00:00
abstract::We describe the preparation of monodisperse, lanthanide-doped hexagonal-phase NaYF4 upconverting luminescent nanoparticles for protein conjugation. Their core was coated with a silica shell which then was modified with a poly(ethylene glycol) spacer and N-hydroxysuccinimide ester groups. The nanoparticles were charact...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.5113
更新日期:2013-03-13 00:00:00
abstract::The α-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G(αI) protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has also been identified as a strong chemoattractant for HSPCs and imp...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.4621
更新日期:2013-01-01 00:00:00
abstract::Due to their tunable surface plasmon and photothermal effects, gold nanorods (AuNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery. All these applications can be remotely controlled by near infrared (NIR) light which can penetrate deep in...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.5409
更新日期:2013-01-01 00:00:00